Synthetic Chemistry and Drug Discovery Research Group
翟宏斌 Hongbin Zhai
Principal Investigator, Professor, School of Chemical Biology & Biotechnology, PKUSZ
Tel: +86-755-2603-2190
Fax: +86-755-2603-3174
E-mail: zhaihb@pku.edu.cn
Web: https://web.pkusz.edu.cn/zhai/
EDUCATION & EXPERIENCE
2015-Present |
Professor, Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, China |
2010-2015 |
Professor and Director, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, China |
2000-2010 |
Professor, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China |
1998-2000 |
Postdoctoral Research Associate, with Professor Henry Rapoport, Department of Chemistry, University of California, Berkeley, California |
1996-1997 |
Postdoctoral Research Associate, with Professor Albert Soloway, College of Pharmacy, The Ohio State University, Columbus, Ohio |
1989-1995 |
Ph.D., Organic Chemistry , The Ohio State University, Columbus, Ohio |
1985-1988 |
M.S., Pharmacognocy/Analytical Chemistry, Peking Union Medical College, Beijing |
1981-1985 |
B.S., Radiochemistry/Applied Chemistry, Peking University, Beijing |
HONORS AND AWARDS
1. High-Tier Talent Team Program, Shenzhen (2020)
2. National Ten Thousand Talent Program (2017)
3. Tier-A Pioneering Talent Program of Nanshan District (2017)
4. Innovation Team in the Key Areas of Innovation Talent Promotion Program, Ministry of Science and Technology (2016)
5. Lectureship Awards of Asian Core Program, (2013, 2012, 2011, 2008, 2006)
6. New Century Talent Program of National Tier Program (2009)
7. “Distinguished Young Investigator” Program, National Natural Science Foundation of China (2006)
8. Post-Venus Program, Science and Technology Commission of Shanghai Municipal (2005)
9. Venus Program, Science and Technology Commission of Shanghai Municipal (2002)
10. Hundreds of Talent Program, Chinese Academy of Sciences (1999)
RESEARCH INTERESTS
1. Total synthesis of natural products
2. Heterocyclic chemistry/medicinal chemistry
3. Synthetic methodology development
SELECTED PUBLICATIONS
1. Yao, J.; Ding, R., Chen, X.; Zhai, H.* Asymmetric Total Synthesis of (+)-Alstonlarsine A, J. Am. Chem. Soc. 2022, 144, 14396.
2. Qing, Z.; Mao, P.; Wang, T.; Zhai, H.* Asymmetric Total Syntheses of Cephalotane-Type Diterpenoids Cephanolides A–D, J. Am. Chem. Soc. 2022, 144, 10640.
3. Ao, Q.#; Zhang, H.#; Zheng, J.; Chen, X.*; Zhai, H.* Asymmetric Total Synthesis of (+)-Mannolide C, Angew. Chem. Int. Ed. 2021, 60, 21267.
4. Xu, B.#; Xun, W.#; Su, S.; Zhai, H.* Total Syntheses of (–)-Conidiogenone B, (–)-Conidiogenone and (–)-Conidiogenol, Angew. Chem. Int. Ed. 2020, 59, 16475.
5. Zhang, Z.; Xie, S.; Cheng, B.; Zhai, H.*; Li, Y.*, Enantioselective Total Synthesis of (+)-Arboridinine, J. Am. Chem. Soc. 2019, 141, 7147.
6. Chen, X.#; Zhang, H.#; Yang, X.; Lv, H.; Shao, X.; Tao, C.; Wang, H.; Cheng, B.; Li, Y.; Guo, J.; Zhang, J.; Zhai, H.* Divergent Total Syntheses of (-)-Daphnilongeranin B and (-)-Daphenylline, Angew. Chem. Int. Ed. 2018, 57, 947.
7. Zhang, H.#; Hu, L.#; Ma, Z.; Li, R.; Zhang, Z.; Tao, C.; Cheng, B.; Li, Y.; Wang, H.; Zhai, H*, Total Synthesis of Diterpenoid (+)-Harringtonolide, Angew. Chem. Int. Ed. 2016, 55, 11638.
8. Chen, X.; Duan, S.; Tao, C.; Zhai, H.*; Qiu, F. G.* Total Synthesis of (+)-Gelsemine via an Organocatalytic Diels-Alder Approach, Nat. Commun. 2015, 6, 7204.
9. Chen, J.; Gao, P.; Yu, F.; Yang, Y.; Zhu, S.; Zhai, H.* Total Synthesis of (±)-Merrilactone A, Angew. Chem. Int. Ed. 2012, 51, 5897.
10. Zhang, W.; Luo, S.; Fang, F.; Chen, Q.; Hu, H.; Jia, X.; Zhai, H.* Total Synthesis of Absinthin, J. Am. Chem. Soc. 2005, 127, 18.
