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Education & Experience
2016 – Associate Professor, Peking University, Shenzhen Graduate School
2012 – 2016 Postdoctoral Fellow, The Rockefeller University, USA (Supervisor: Prof. Howard C. Hang)
2010 – 2011 Research Associate, The University of Hong Kong (Supervisor: Prof. Dan Yang)
2004 – 2009 Ph.D., Chemistry, The University of Hong Kong (Advisor: Prof. Dan Yang)
2000 – 2004 B.Sc., Chemistry, Peking University (Advisor: Prof. Na Li)
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Research Fields
Our group’s research interests mainly lie in the field of Chemical Biology, focusing on the development and application of small-molecule chemical tools, such as fluorescent probes, photocrosslinking probes, bioorthogonal chemical reporters, and so on, in combination with cutting-edge proteomics and traditional biology methods, to understand the molecular and cellular mechanisms of biological processes, especially the pathological processes of human diseases with a special focus on neurodegenerative diseases and cancer. A better understanding of the underlying pathological mechanisms of human diseases will enable the identification of novel therapeutic targets and ultimately promote the development of new therapeutic strategies and small-molecule drugs. We employ multidisciplinary techniques from organic synthesis, biochemistry, cell biology, and mass spectrometry to approach these important biological questions.
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Selected Publications
1. Peng, T.; Chen, X.; Gao, L.; Zhang, T.; Wang, W.; Shen, J.; Yang, D., A rationally designed rhodamine-based fluorescent probe for molecular imaging of peroxynitrite in live cells and tissues. Chem. Sci. 2016, in press.
2. Peng, T.; Hang, H. C., Bifunctional fatty acid chemical reporter for analyzing S-palmitoylated membrane protein-protein interactions in mammalian cells. J. Am. Chem. Soc. 2015, 137, 556–559.
3. Burnaevskiy, N.; Peng, T.; Reddick, L. E.; Hang, H. C.; Alto, N. M., Myristoylome profiling reveals a concerted mechanism of ARF GTPase deacylation by the bacterial protease IpaJ. Mol. Cell 2015, 58, 110–122.
4. Santiago-Tirado, F. H.; Peng, T.; Yang, M.; Hang, H. C.; Doering, T. L., A single protein S-acyltransferase is a major determinant of cryptococcal pathogenesis. PLoS Pathog. 2015, 11, e1004908.
5. Peng, T.; Wong, N.-K.; Chen, X.; Chan, Y.-K.; Ho, D. H.-H.; Sun, Z.; Hu, J. J.; Shen, J.; El-Nezami, H.; Yang, D., Molecular imaging of peroxynitrite with HKGreen-4 in live cells and tissues. J. Am. Chem. Soc. 2014, 136, 11728–11734.
6. Peng, T.; Yuan, X.; Hang, H. C., Turning the spotlight on protein–lipid interactions in cells. Curr. Opin. Chem. Biol. 2014, 21, 144–153.
7. Peng, T.; Yang, D., HKGreen-3: a rhodol-based fluorescent probe for peroxynitrite. Org. Lett. 2010, 12, 4932–4935.
8. Peng, T.; Yang, D., Construction of a library of rhodol fluorophores for developing new fluorescent probes. Org. Lett. 2010, 12, 496–499.
